Authors: Lob, Patrick; Hessel, Volker; Klefenz, Heinrich; Lowe, Holger; Mazanek, Kyra

Source: Letters in Organic Chemistry, Volume 2, Number 8, December 2005 , pp. 767-779(13)

Publisher: Bentham Science Publishers

Abstract:

A solvent-free continuous bromination reaction of thiophene in a micro reactor rig was developed, using pure bromine and aromatic without any catalyst at room temperature processing. This micro-reactor operation led to high selectivities for the bromination of 2,5-dibromo-thiophene (at about complete conversion) and yields up to 86%, which is better than for self-made batch processing (77% yield) and literature data (50% yield). In addition, the reaction time could be reduced from about 2 hours to less than 1 second. Correspondingly, the space-time yields were higher by order of magnitude for the continuous microreactor process as compared to batch operation. The micro reactor allowed a fast parametric study and in this way to reliably find optimal operating conditions with regard to temperature and the bromine-to-thiophene molar ratio. The study was complemented by a comparison of two different micro mixers, a T-junction with minute internals, and batch processing under optimal conditions.

Keywords: Chemical micro process engineering; Micro reactors; Brominations; Thiophene bromination

Document Type: Review article

DOI: http://dx.doi.org/10.2174/157017805774717517

Affiliations: 1: Institut für Mikrotechnik Mainz GmbH, Carl-Zeiss-Str. 18-20, 55129 Mainz, Germany.

Publication date: 2005-12-01

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