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Solvent-Free Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones Using Trichloroisocyanuric Acid

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An efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) using trichloroisocyanuric acid (TCICA) under solvent-free conditions is reported.

Keywords: 3,4-dihydropyrimidin-2(1H)-ones; Biginelli reaction; condensation reaction; solvent-free conditions; trichloroiscyanuric acid

Document Type: Review Article

Affiliations: Department of Chemistry, College of Science, Guilan University, Rasht, zip code 41335, Iran.

Publication date: 01 December 2005

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.
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