The Total Synthesis of Pitipeptolide A
An efficient synthesis of the marine cyanobacterium metabolite pitipeptolide A is presented. The approach incorporates a variety of peptide coupling methods, asymmetric synthesis and macrocyclization. The route is versatile and allows scope for structural modification.
Keywords: Cyanobacteria; Depsipeptide; Lyngbya majuscula; Macrocyclization; Total synthesis
Document Type: Review Article
Affiliations: Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China
Publication date: 01 December 2005
- Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
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