1,10-Epoxyhypocretenolides from the Azorean Endemic Leontodon rigens (Asteraceae)
Abstract:A methanolic extract of Leontodon rigens (Dryander in Aiton) Paiva & Ormonde yielded 1,10- epoxy-14-hydroxyhypocretenolide-β-D-glucopyranoside and its 6'-O-p-hydroxyphenylacetyl derivative. These compounds represent the first epoxyguaian-12,5-olide derivatives. The structures were established by means of high resolution mass spectrometry and 1-D and 2-D NMR spectroscopy. The cytotoxicity of the isolated compounds was assessed using the MTT assay and their potential to induce apoptosis by employing the annexin V-PI assay.
Document Type: Review Article
Affiliations: Institut fur Pharmazie, Abteilung Pharmakognosie, Leopold-Franzens-Universitat,A-6020 Innsbruck, Austria.
Publication date: August 1, 2005
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