Synthesis and in Vitro Anti-Proliferative Activity of Racemic Trifluoro-Casodex® (Bicalutamide)
Authors: Sani, M.; Viani, F.; Binda, M.; Zaffaroni, N.; Zanda, M.
Source: Letters in Organic Chemistry, Volume 2, Number 5, August 2005 , pp. 447-449(3)
Publisher: Bentham Science Publishers
Abstract:The trifluoro analogue 1 of Casodex® was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro antiproliferative activity on the human prostate cancer cell line LNCaP.
Document Type: Review Article
Affiliations: Dipartimento di Chimica, Materiali ed Ingegneria Chimica “G. Natta” del Politecnico di Milano and C.N.R .- Istituto di Chimica del Riconoscimento Molecolare, Sezione “A. Quilico”, via Mancinelli 7, I-20131 Milano, Italy.
Publication date: August 1, 2005
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