Three Components Coupling Catalysed by Na2CaP2O7: Synthesis of α-Amino Phosphonates Under Solvent-Free Conditions at Room Temperature

Authors: Zahouily, M.; Elmakssoudi, A.; Mezdar, A.; Rayadh, A.; Sebti, S.; Lazrek, H. B.

Source: Letters in Organic Chemistry, Volume 2, Number 5, August 2005 , pp. 428-432(5)

Publisher: Bentham Science Publishers

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Abstract:

Synthetic phosphate Na2CaP2O7 has been utilized as an efficient catalyst for the three components coupling of carbonyl compounds, aromatic and aliphatic amines and dialkyl phosphite to produce α-amino phosphonates. The reaction was carried out under solvent-free conditions at room temperature. The by-product H2O formed during the reaction increases the catalytic activity of Na2CaP2O7.

Keywords: synthetic phosphate; amino phosphonates; heterogeneous catalysis; recyclable catalyst

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570178054405887

Affiliations: 1: Laboratoire de Catalyse, Chimiometrie et Environnement, UFR de Chimie Appliquee, Faculte des Sciences et Techniques, Universite Hassan II, Mohammedia B. P. 146, 20650 Maroc.

Publication date: 2005-08-01

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