Synthesis of Azlactones, Phenylpyruvic Acid and 1,2,4-Triazine Derivatives Under Microwave Irradiation
Authors: El Ashry, E. S.H.; Ramadan, E. S.; Hamid, H. A.; Hagar, M.
Source: Letters in Organic Chemistry, Volume 2, Number 5, August 2005 , pp. 415-418(4)
Publisher: Bentham Science Publishers
Abstract:Microwave (MW) irradiation has been used in each step for the transformation of acyl glycines 2 to 6-benzyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one (7a), and its 4-phenyl derivatives 7b and 7c. The oxazolone 3a was also transformed to phenylpyruvic acid 5, whose thiosemicarbazone 6 can be cyclized to 7a under MW. Methylation of 7c gave the respective S- and / or N-methylated derivatives, 8 and 9, based on the reaction conditions.
Document Type: Review Article
Affiliations: Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt;
Publication date: August 1, 2005
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