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Synthesis of Azlactones, Phenylpyruvic Acid and 1,2,4-Triazine Derivatives Under Microwave Irradiation

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Microwave (MW) irradiation has been used in each step for the transformation of acyl glycines 2 to 6-benzyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one (7a), and its 4-phenyl derivatives 7b and 7c. The oxazolone 3a was also transformed to phenylpyruvic acid 5, whose thiosemicarbazone 6 can be cyclized to 7a under MW. Methylation of 7c gave the respective S- and / or N-methylated derivatives, 8 and 9, based on the reaction conditions.
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Keywords: azlactones; microwave; phenylpyruvic acid; thiosemicarbazone; triazine

Document Type: Review Article

Affiliations: Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt;

Publication date: 2005-08-01

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