A Facile Synthesis of Chiral Isocyanate-phenol and Unsymmetrical Urea Derived from Tyrosines without Protecting Phenolic Hydroxyl Groups
A facile method for synthesis and isolation of chiral isocyanate-phenols, obtained from the reactions of L-tyrosine and L-DOPA [L-3-(3,4-dihydroxyphenyl)alanine] derivatives with di-tert-butyltricarbonate (DBTC), is described. Reaction of the obtained isocyanate-phenol with n-butylamine gave the corresponding chiral unsymmetrical urea.
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Document Type: Review Article
Affiliations: Department of Polymer Science and Engineering, Faculty of Engineering, Yamagata University 4- 3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan;
Publication date: 2005-08-01
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