One-Pot, Regioselective Synthesis of 1,3,5 Trisubstituted Hydantoins by Domino Condensation / aza-Michael / O→N acyl Migration of Asymmetric Carbodiimides with α,β-Unsaturated Carboxylic Acids
1,3,5 Trisubstituted hydantoins having two different substituents at the nitrogen atoms could be smoothly prepared by a domino condensation / aza-Michael / O→N acyl migration of asymmetric carbodiimides with activated α,β-unsaturated carboxylic acids. The regiochemical outcome of the process, as well as scope and limits, are discussed.
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Document Type: Review Article
Affiliations: Dipartimento di Chimica, Materiali ed Ingegneria Chimica “G. Natta” del Politecnico di Milano, via Mancinelli 7, I-20131 Milano, Italy.
Publication date: 2005-02-01
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