Highly Diastereoselective Methylation of Five-Ring N,O-Acetals
Highly diastereoselective methylation of (2S,4S)- and (2R,4S)-3-tert-butyl 4-methyl 2-tertbutyloxazolidine- 3,4-dicarboxylate (1a / b) is reported. The relative and absolute configuration of the methylated products was assigned by NOESY and confirmed by a crystal structure of 1a.
Keywords: alkylation; amino acids; diastereoselectivity
Document Type: Review Article
Affiliations: Laboratory of Organic Chemistry, Helsinki University of Technology, P.O. Box 6100, FIN - 02150 Espoo, Finland
Publication date: 01 July 2004
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