Synthesis of N-(Trimethylsilylethoxycarbonyl)-deoxycytidine and Deoxyadenosine Derivatives as Key Intermediates for the DNA Synthesis using Fluoride Ion-Promoted Deprotection Strategy
Authors: Sekine, Mitsuo; Tobe, Masanori; Nagayama, Takashi; Wada, Takeshi
Source: Letters in Organic Chemistry, Volume 1, Number 2, April 2004 , pp. 179-182(4)
Publisher: Bentham Science Publishers
Abstract:An improved method for the synthesis of trimethylsilylethyl chloroformate (Teoc-Cl) was studied in great detail. N-Teoc-adenosine, N-Teoccytidine and their deoxyribonucleoside derivatives were synthesized as the key synthetic intermediates for the synthesis of base-sensitive oligonucleotide derivatives by use of N-methylimidazole. The stability and chemical properties of these Nprotected nucleoside derivatives were examined.
Document Type: Review Article
Affiliations: CREST, JST (Japan Science and Technology Agency), Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama 226-8501, Japan.
Publication date: April 1, 2004
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