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Cytotoxic Resibufogenin Transformation Products from Cell Suspension Cultures of Platycodon Grandiflorum

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Four biotransformed products of resibufogenin were obtained after 4 days of incubation with cell suspension cultures of Platycodon grandiflorum. On the basis of chemical and spectral data, their structures were elucidated as 3-epi-resibufogenin, marinobufagin, 1β-hydroxy-resibufogenin, and 3-epi-marinobufagin respectively, among which the latter two compounds are new. These compounds were found to exhibit potent cytotoxic activities against Bel-7402, BGC-823, HeLa, and HL-60 human cancer cell lines.
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Keywords: biotransformation; campanulaceae; platycodon grandiflorum; resibufogenin

Document Type: Review Article

Affiliations: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, P. R. China.

Publication date: 2004-04-01

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