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Cytotoxic Resibufogenin Transformation Products from Cell Suspension Cultures of Platycodon Grandiflorum

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Four biotransformed products of resibufogenin were obtained after 4 days of incubation with cell suspension cultures of Platycodon grandiflorum. On the basis of chemical and spectral data, their structures were elucidated as 3-epi-resibufogenin, marinobufagin, 1β-hydroxy-resibufogenin, and 3-epi-marinobufagin respectively, among which the latter two compounds are new. These compounds were found to exhibit potent cytotoxic activities against Bel-7402, BGC-823, HeLa, and HL-60 human cancer cell lines.

Keywords: biotransformation; campanulaceae; platycodon grandiflorum; resibufogenin

Document Type: Review Article


Affiliations: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, P. R. China.

Publication date: April 1, 2004

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  • Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
    The journal is essential reading for all organic chemists both in academia and industry.

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