Fine-Tuning of Acid Susceptibility of 4, 4’-Dimethoxytrityl Ether Derivatives by a Methoxy Group Introduced via a Styryl Substituent
To overcome the problem of depurination in oligoDNA synthesis, we tried to fine-tune the acid lability of the DMTr group by adding a substituted styryl group on the phenyl ring. The styryl groups could buffer the electron donating nature of the methoxy group and enabled the fine-tuning of the acid lability.
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Document Type: Review Article
Affiliations: CREST, JST (Japan Science and Technology Agency) Nagatsuta-cho, Midori-ku, Yokohama 226- 8501, Japan.
Publication date: 2004-04-01
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