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Fine-Tuning of Acid Susceptibility of 4, 4’-Dimethoxytrityl Ether Derivatives by a Methoxy Group Introduced via a Styryl Substituent

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Abstract:

To overcome the problem of depurination in oligoDNA synthesis, we tried to fine-tune the acid lability of the DMTr group by adding a substituted styryl group on the phenyl ring. The styryl groups could buffer the electron donating nature of the methoxy group and enabled the fine-tuning of the acid lability.

Keywords: depurination; oligodeoxynucleotide synthesis; protecting group; trityl group

Document Type: Review Article

DOI: https://doi.org/10.2174/1570178043488428

Affiliations: CREST, JST (Japan Science and Technology Agency) Nagatsuta-cho, Midori-ku, Yokohama 226- 8501, Japan.

Publication date: 2004-04-01

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