Synthesis and Cellular Uptake of Fluorescently Labeled 1-Chloromethyl-5- Hydroxy-1, 2-Dihydro-3H-Benz [e] Indole (Seco-CBI)- Pyrrole Polyamide Conjugates
Abstract:The synthesis is described of 1-chloromethyl-5-hydroxy-1, 2-dihydro-3H-benz [e] indole (seco- CBI)- pyrrole polyamide conjugates (1-4) which were labeled with a fluorescent Fmoc moiety to evaluate their cellular uptake. Confocal laser scanning microscopy (CLSM) indicates that these DNA minor groove-binding agents localize in the cytoplasm and organelles.
Document Type: Review Article
Affiliations: Department of Chemistry, University of Alberta, Edmonton, AB, Canada, T6G 2G2.
Publication date: 2004-04-01
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