3D-QSAR Study of Some Heterocyclic Sulfonamide Analogs as hCAII Inhibitors
Keywords: 3D QSAR analysis; 3D-QSAR; Carbonic anhydrase inhibitors; CoMFA; CoMSIA; Comparative Molecular Field Analysis; Docking; Gaster-Huckel method; Gaussian function; Tripos force field; bioactive; hCA II; metallo-enzymes; of leave-one-out method; pharmacophore; sulfonamide group
Document Type: Research Article
Affiliations: Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra Ranchi- 835215, India.
Publication date: 2012-07-01
- Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.