Current Perspectives on Anti-Aging Interventions

Authors: Ibrahim Rizvi, Syed; Jha, Rashmi

Source: Letters in Drug Design & Discovery, Volume 7, Number 5, June 2010 , pp. 379-388(10)

Publisher: Bentham Science Publishers

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Abstract:

Aging is an inherently complex process and the manifestations occur within an organism at genetic, molecular, cellular, organ, and system levels. It is now believed that aging results from a complex interplay between multiple mechanisms including oxidative stress, mitochondrial DNA damage, membrane alterations, telomere loss, apoptosis and genetic mechanisms. All the above mentioned processes contribute towards the process of aging and may underlie the age related changes. The current understanding of aging process has given novel insights in potential anti-aging interventions. The current strategies for anti-aging interventions include anti-oxidant supplementation, hormonal treatment, caloric restriction, and genetic and cellular engineering techniques. Any given intervention to be acknowledged as anti-aging must be able to demonstrate delayed onset or pace of multiple age-related changes and pathologies and also to bring the health span closer to the life span.

Keywords: Anti-aging; Anti-oxidant supplementation; Caloric restriction

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018010791163488

Publication date: 2010-06-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.