Letters in Drug Design & Discovery

Is DNA Minor Groove Binding Crucial for Biological Activity of Triazoloacridinones with Cytotoxic and Antitumour Properties?
pp. 242-245(4)
Authors: Koba, Marcin; Koba, Katarzyna; Baczek, Tomasz

DNA Binders: 2. Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1Hpyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents
pp. 246-251(6)
Authors: Dallocchio, Roberto; Dessi, Alessandro; Sanna, Vanna; Pala, Nicolino; Campesi, Ilaria; Paglietti, Giuseppe; Sechi, Mario

Synthesis and Biological Evaluation of a Series of 4-(arylamido/imidoalkyl)- 5-(arylideno- 4-oxo-2-thio-imidazolidinyl)-N-(methyl-phenyl-imino) Acridinium Iodides as Potential Antiviral Agents
pp. 252-257(6)
Authors: Bishnoi, Abha; Saxena, Rashmi; Singh, Suruchi; Rani, Archna; Joshi, M. N.; Bajpai, S. K.

Design, Synthesis and Preliminary Screening of Some New Conformationally Constrained Falcipain-2 Inhibitors as Potential Antimalarial Agents
pp. 258-267(10)
Authors: Shinde, Anil K.; Chouhan, Bishram S.; Dasgupta, Shirshendu; Giridhar, Rajani; Rosenthal, Philip; Gut, Jiri; Yadav, Mange R.

Synthesis of Substituted Pyrimidinedione Derivatives as Potential Schistosomicidal Agents
pp. 268-277(10)
Authors: Saudi, Manal N.S.; Youssef, Amal M.; Badr, Mona H.; Elbayaa, Rasha Y.; El-azzouni, Mervat Z.; Mossallam, Shereen F.; Baddour, Nahed M.; Eissa, Maha M.

Combination of Time-Dependent and pH-Dependent System for Intestinal Delivery of 4-Aminosalicylic Acid Based Pellets
pp. 278-285(8)
Authors: Youm, Ibrahima; Lahiani-Skiba, Malika; Bounoure, Frederic; Skiba, Mohamed

Comparative QSAR Studies on the Novel Series of Thiazolones and Tetrazole Derivatives as HCV NS5B Polymerase Allosteric Inhibitors
pp. 286-297(12)
Author: Singh, Shalini

Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study
pp. 298-303(6)
Authors: Romagnoli, Romeo; Baraldi, Pier G.; Carrion, Maria D.o.r.a.; Cruz-Lopez, Olga; Cara, Carlota L.o.p.e.z.; Preti, Delia; Tabrizi, Mojgan A.g.h.a.z.a.d.e.h.; Balzarini, Jan; Hamel, Ernest; Fabbri, Enrica; Gambari, Roberto

Physicochemical and Pharmacological Characterization of Etodolac- Loaded Poloxamer Gel as a Rectal Delivery System
pp. 304-311(8)
Authors: Barakat, Nahla S.; El-Maradny, Hoda M.

Use of Pre-Clinical In Vitro and In Vivo Pharmacokinetics for the Selection of a Potent Hepatitis C Virus Protease Inhibitor, Boceprevir, for Clinical Development
pp. 312-318(7)
Authors: Cheng, K.-C.; Li, Cheng; Liu, Tongtong; Wang, Ganfeng; Hsieh, Yunsheng; Pavlosky, Anastasia; Broske, Lisa; Prelusky, Dan; Liu, Rong; White, Ronald E.; Uss, Annette S.; Gupta, Samir; Njoroge, F. G.