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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Publisher: Bentham Science Publishers

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Volume 6, Number 4, June 2009

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Articles

DNA Binders: 2. Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1Hpyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents
pp. 246-251(6)
Authors: Dallocchio, Roberto; Dessi, Alessandro; Sanna, Vanna; Pala, Nicolino; Campesi, Ilaria; Paglietti, Giuseppe; Sechi, Mario

Design, Synthesis and Preliminary Screening of Some New Conformationally Constrained Falcipain-2 Inhibitors as Potential Antimalarial Agents
pp. 258-267(10)
Authors: Shinde, Anil K.; Chouhan, Bishram S.; Dasgupta, Shirshendu; Giridhar, Rajani; Rosenthal, Philip; Gut, Jiri; Yadav, Mange R.

Synthesis of Substituted Pyrimidinedione Derivatives as Potential Schistosomicidal Agents
pp. 268-277(10)
Authors: Saudi, Manal N.S.; Youssef, Amal M.; Badr, Mona H.; Elbayaa, Rasha Y.; El-azzouni, Mervat Z.; Mossallam, Shereen F.; Baddour, Nahed M.; Eissa, Maha M.

Combination of Time-Dependent and pH-Dependent System for Intestinal Delivery of 4-Aminosalicylic Acid Based Pellets
pp. 278-285(8)
Authors: Youm, Ibrahima; Lahiani-Skiba, Malika; Bounoure, Frederic; Skiba, Mohamed

Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study
pp. 298-303(6)
Authors: Romagnoli, Romeo; Baraldi, Pier G.; Carrion, Maria D.o.r.a.; Cruz-Lopez, Olga; Cara, Carlota L.o.p.e.z.; Preti, Delia; Tabrizi, Mojgan A.g.h.a.z.a.d.e.h.; Balzarini, Jan; Hamel, Ernest; Fabbri, Enrica; Gambari, Roberto

Use of Pre-Clinical In Vitro and In Vivo Pharmacokinetics for the Selection of a Potent Hepatitis C Virus Protease Inhibitor, Boceprevir, for Clinical Development
pp. 312-318(7)
Authors: Cheng, K.-C.; Li, Cheng; Liu, Tongtong; Wang, Ganfeng; Hsieh, Yunsheng; Pavlosky, Anastasia; Broske, Lisa; Prelusky, Dan; Liu, Rong; White, Ronald E.; Uss, Annette S.; Gupta, Samir; Njoroge, F. G.

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