Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators

Authors: Sha, Xiangyang; Zhang, Huibin; Huang, Wenlong; Zhou, Jinpei; Zhou, Yinghong

Source: Letters in Drug Design & Discovery, Volume 6, Number 3, April 2009 , pp. 224-227(4)

Publisher: Bentham Science Publishers

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Abstract:

In this paper we reported the design, synthesis of a series of thiazolidinedione derivates. Their PPARγ activity in vitro was assessed using a reporter gene assay. In this series, it was demonstrated that compound 8f, 8g and 8h with substituted sulfonamino thiourea groups exhibited significant partial agonistic effects on PPARγ.

Keywords: Diabetes; PPAR; Synthesis; Thiazolidinedione; Sulfonamino thiourea

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018009787847819

Publication date: 2009-04-01

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