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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Publisher: Bentham Science Publishers

Volume 5, Number 8, December 2008
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Articles

Telmisartan Blocks Advanced Glycation End Product (AGE)-Induced Plasminogen Activator Inhibitor-1 (PAI-1) Gene Expression in Endothelial Cells via Activation of Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ )
pp. 477-480(4)
Authors: Matsui, Takanori; Nakamura, Kazuo; Takeuchi, Masayoshi; Yamagishi, Sho-ichi

Synthesis and Biological Evaluation of Novel 6-Deoxy-β -D-Psicofuranosyl Mercaptoheterocyclic Compounds
pp. 481-484(4)
Authors: De Lade, I. G.; Braga, F. G.; Grazul, R. M.; Coimbra, E. S.; Da Silva, A. D.

Microwave-Assisted Synthesis of Imido-Substituted 2-Chloro-1,4-naphthoquinone Derivatives and their Cytotoxic Activities on Three Human Prostate Cancer Cell Lines
pp. 485-488(4)
Authors: Berhe, Solomon; Kanaan, Yasmine; Copeland Jr., Robert L.; Wright, Dwayne A.; Zalkow, Leon H.; Bakare, Oladapo

Antitumor Activity of Oxali-Titanocene Y in Xenografted CAKI-1 Tumors in Mice
pp. 489-493(5)
Authors: Fichtner, Iduna; Behrens, Diana; Claffey, James; Gleeson, Brendan; Hogan, Megan; Wallis, Denise; Weber, Holger; Tacke, Matthias

Multidimensional Consensus QSAR: A Step towards Integrating CoMFA, CoMSIA with Traditional QSAR Methodologies (Supplementary Data)
pp. 494-502(9)
Authors: Dewangan, P.; Verma, S. M.; Basu, A.; J., Venkatesan

Synthesis of a Novel Series of 8-HETE Analogs and their Biological Evaluation Towards the PPAR Nuclear Receptors
pp. 503-511(9)
Authors: Liutkus, Melanie; Dacquet, Catherine; Audinot-Bouchez, Valerie; Boutin, Jean; Caignard, Daniel-Henri; Ktorza, Alain; Gree, Rene

Molecular Modeling of Flavonoid-β-Cyclodextrin Complexes
pp. 512-520(9)
Authors: Zheng, Ying; Chow, Albert H.L.; Haworth, Ian S.

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