96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

Authors: Heikkila, Tiina; Peltonen, Leena; Taskinen, Saila; Laaksonen, Timo; Hirvonen, Jouni

Source: Letters in Drug Design & Discovery, Volume 5, Number 7, October 2008 , pp. 471-476(6)

Publisher: Bentham Science Publishers

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Abstract:

Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.

Keywords: Solubility; Surface tension; Ibuprofen; Indomethacin; High throughput screening (HTS); 96-well plate

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018008785909840

Publication date: 2008-10-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.