Synthesis and Biological Evaluation of a New Series of Benzothiazole-Quinolone Hybrids as Antibacterial Agents

Authors: Kamal, Ahmed; Ahmed, S. K.; A. Khan, M. N.a.s.e.e.r.; Shetty, Rajesh V.C.R.N.C.; Siddhardha, B.; Murty, U. S.N.

Source: Letters in Drug Design & Discovery, Volume 5, Number 5, July 2008 , pp. 353-357(5)

Publisher: Bentham Science Publishers

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Abstract:

In an effort to develop new and more effective therapies to treat bacterial infection, quinolone coupled benzothiazoles (6a-f) have prepared and evaluated for their efficacy as antibacterial agents against various Gram-positive and Gram-negative strains of bacteria. Some of the compounds from this series exhibited antibacterial activity comparable to ciprofloxacin.

Keywords: Benzothiazoles; Quinolones; Antibacterial activity

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018008784912072

Publication date: 2008-07-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.