Tetrahydroisoquinoline-Related Modulators of Multidrug Resistance in Cancer

Authors: Li, Yu; Zhang, Hui B.; Huang, Wen L.o.n.g.; Zhen, Xia; Li, Yun M.a.n.

Source: Letters in Drug Design & Discovery, Volume 5, Number 4, June 2008 , pp. 303-306(4)

Publisher: Bentham Science Publishers

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Abstract:

A series of novel tetrahydroisoquinoline derivatives (7a-b and 8a-j) were synthesized by using N-cyanoguanyl as a spacer, and their multidrug resistance reversal activities against K562/A02 cell line in vitro were evaluated by MTT method. It was found that 7a and 8b showed more potent multidrug resistance reversal activities than verapamil.

Keywords: Tetrahydroisoquinoline; N-cyanoguanyl; Synthesis; MDR; Modulator; P-glycoprotein

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018008784619834

Publication date: 2008-06-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.