Propofol and Systemic Inflammatory Response in Abdominal Aortic Surgery

Authors: Rodriguez-Lopez, Jose M.; Lozano, Francisco S.

Source: Letters in Drug Design & Discovery, Volume 5, Number 2, March 2008 , pp. 148-151(4)

Publisher: Bentham Science Publishers

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Abstract:

Abdominal aortic surgery is relatively common associated with considerable postoperative morbidity and mortality. The aortic cross-clamping for the implantation of a vascular prosthetic graft induces a systemic inflammatory response (SIR) because of an ischemia-reperfusion (IR) injury. In our experimental models we have reported that propofol anesthesia, compared with sevoflurane, after IR modulates SIR and this effect might result in renal protection.

Keywords: Propofol; Systemic inflammatory response; Aortic surgery; Aortic cross-clamping

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018008783928490

Publication date: 2008-03-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.