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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Publisher: Bentham Science Publishers

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Volume 5, Number 2, March 2008

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Articles

CoMFA Study on Thiazolidine-2,4-diones for their Antihyperglycemic Activity
pp. 79-87(9)
Authors: Prashantha Kumar, B. R.; Desai, Bijoy J.; Vergheese, J.; Praveen, T. K.; Suresh, B.; Nanjan, M. J.

Artepillin C: A Review
pp. 88-92(5)
Authors: Duque Estrada, Gizelda O.; Mendes da Silva, Joaquim F.e.r.n.a.n.d.o.; Ceva Antunes, Octavio A.u.g.u.s.t.o.

Synthesis and Photobiological Properties of Bromo- and Alkoxymethyl Furocoumarins
pp. 93-103(11)
Authors: Viola, Giampietro; Boccalini, Marco; Fortunato, Elena; dall'Acqua, Francesco; Chimichi, Stefano

New Peptidic Neuroprotectants Against NMDA Neurotoxicity: Syntheses and Biological Evaluations of Linear Complestatin Analogs
pp. 104-107(4)
Authors: Park, Ho-Joon; Kim, Seung-Woo; Shin, Young-Gyun; Kim, Yun-Jung; Lee, Ja-Kyeong; Kong, Suk B.; Yoon, Sung-Hwa

Phenylpyazoleanilides as a Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 1: A New Class of Orally Available Immunomodulators
pp. 111-115(5)
Authors: Ushio, Hiroyuki; Ishibuchi, Seigo; Adachi, Kunitomo; Oshita, Kouichi; Chiba, Kenji

Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase. 2. Investigation of the Carboxamide Portion of Spirocyclic Piperidine Amides
pp. 116-121(6)
Authors: Costanzo, Michael J.; Yabut, Stephen C.; Zhang, Han-Cheng; White, Kimberley B.; Wang, Yuanping; Minor, Lisa K.; Tounge, Brett A.; Barnakov, Alexander N.; Lewandowski, Frank; Milligan, Cynthia; Spurlino, John C.; Maryanoff, Bruce E.

Synthesis and Biological Activity of New Tricyclic Purine Derivatives Obtained by Intramolecular N-7 Alkylation
pp. 122-126(5)
Authors: Lino Carmo, Arturene M.; Braga, Fernanda G.a.m.b.o.g.i.; De Paula, Marcio L.u.i.z.; Ferreira, Ana P.a.u.l.a.; Teixeira, Henrique C.o.u.t.o.; da Silva, Adilson D.a.v.i.d.; Coimbra, Elaine S.o.a.r.e.s.

Design and Synthesis of Novel Diaryl Heterocyclic Derivatives as Selective Cyclooxygenase-2
pp. 127-133(7)
Authors: Li, S. X.; Deng, X. D.; Jiang, F. L.; Zhao, Y. J.; Xiao, W. S.; Kuang, X. Z.; Sun, X. M.

Mycophenolate Mofetil for the Treatment of Systemic Sclerosis
pp. 134-136(3)
Authors: Naik, Manisha; Shenin, Max; Derk, Chris T.

Synthesis and Antitubercular Evaluation of N'-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide Derivatives
pp. 137-140(4)
Authors: Ferreira, Marcelle de L.; de F. Cardoso, Laura N.; Goncalves, Raoni S.B.; da Silva, Emerson T.; Lourenco, Maria Cristina S.; Vicente, Felipe R.; de Souza, Marcus V.N.

Antitumor Activity of Titanocene Y in Xenografted PC3 Tumors in Mice
pp. 141-144(4)
Authors: Dowling, Catherine M.; Claffey, James; Cuffe, Sandra; Fichtner, Iduna; Pampillon, Clara; Sweeney, Nigel J.; Strohfeldt, Katja; G. Watson, R. W.; Tacke, Matthias

Propofol and Systemic Inflammatory Response in Abdominal Aortic Surgery
pp. 148-151(4)
Authors: Rodriguez-Lopez, Jose M.; Lozano, Francisco S.

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