Authors: Fatima, Angelo d.; Martins, Cleide Viviane B.u.z.a.n.e.l.l.o.; de Resende, Maria A.p.a.r.e.c.i.d.a.; Ferreira Magalhaes, Thais F.u.r.t.a.d.o.; Santiago Lima, Bruno H.e.n.r.i.q.u.e.; Watanabe, Gisele A.l.m.e.i.d.a.; Gois Ruiz, Ana L.T.; de Carvalho, Joao E.r.n.e.s.t.o.; Pilli, Ronaldo A.l.o.i.s.e.

Source: Letters in Drug Design & Discovery, Volume 5, Number 1, January 2008 , pp. 74-78(5)

Publisher: Bentham Science Publishers

Abstract:

A large number of human diseases are caused by fungus and the plant kingdom has proven to be a source of antifungal compounds. This work describes the in vitro activity of the natural product (R)-goniothalamin and its synthetic enantiomer, (S)-goniothalamin, against eleven strains of human pathogenic fungi. The minimum inhibitory concentration (MIC) values for both enantiomers were lower than 100 μg/mL for nine of the fungus strains studied. MIC values for both enantiomers against isolates of the dimorphic fungus Paracoccidioides braziliensis were in the range of 7-22 μg/mL. (R)- and (S)- goniothalamin were selective for the fungi strains presenting minimal toxic effects on mammalian kidney (Vero) and lung (V79) cell lines.

Keywords: Fungi infections; Goniothalamus; Goniothalamin; Antifungal agents; Minimum inhibitory concentration; Antiproliferative activity

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018008783406732

Publication date: 2008-01-01

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• Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

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• In this Subject: Biotechnology ,  Pharmacology
• By this author: Fatima, Angelo d. ;  Martins, Cleide Viviane B.u.z.a.n.e.l.l.o. ;  de Resende, Maria A.p.a.r.e.c.i.d.a. ;  Ferreira Magalhaes, Thais F.u.r.t.a.d.o. ;  Santiago Lima, Bruno H.e.n.r.i.q.u.e. ;  Watanabe, Gisele A.l.m.e.i.d.a. ;  Gois Ruiz, Ana L.T. ;  de Carvalho, Joao E.r.n.e.s.t.o. ;  Pilli, Ronaldo A.l.o.i.s.e.

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