Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library

Authors: Urbano, M.; Collina, S.; Rossi, D.; Baraglia, A. C.; Alcaro, S.; Artese, A.; Azzolina, O.

Source: Letters in Drug Design & Discovery, Volume 4, Number 8, December 2007 , pp. 605-610(6)

Publisher: Bentham Science Publishers

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Abstract:

To discover new potential sigma ligands, a library of 64 members based on a carbamidic scaffold was designed and a synthetic protocol, based on PASPS and MAOS techniques, was developed and optimized. Applying the developed protocol the library compounds were obtained in high purity, suitable for biological screening.

Keywords: Discovery library; Sigma ligands; Arylalkenylamidic scaffold; PASPS; MAOS; Molecular modeling

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018007782794581

Publication date: 2007-12-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.