The Derivation of a Potential Transition-State for the Reduction Reaction Catalysed by 17β -Hydroxysteroid Dehydrogenase Type 3 (17β -HSD) - An Approximate Representation of its Active Site for Use in Drug Design and Discovery

Authors: Olusanjo, Moniola S.; Ahmed, Sabbir

Source: Letters in Drug Design & Discovery, Volume 4, Number 7, October 2007 , pp. 527-531(5)

Publisher: Bentham Science Publishers

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Abstract:

The approximate representation of the active site of the type 3 isozyme of the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD3) has been derived from the consideration of the proposed mechanism for the reduction reaction. Using the transition-state (TS), the mode of action of a number of inhibitors has been rationalised.

Keywords: Type 3; Isozyme; 17β-Hydroxysteroid dehydrogenase; 17β-HSD3; Transition-state; Reduction reaction

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018007781788525

Publication date: 2007-10-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.