Synthesis and Biological Activities of New Triphenyl Organotin (IV) Based on the Pyrazole Carboxylic Acids

Authors: Yahyi, Abderrahmane; Ettouhami, Abdelkader; Radi, Smaail; Zidane, Ismail; Hakkou, Abdelkader; Bouakka, Mohamed

Source: Letters in Drug Design & Discovery, Volume 4, Number 5, July 2007 , pp. 382-385(4)

Publisher: Bentham Science Publishers

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Abstract:

The synthesis of new triphenyltin derivatives with (N-substituted-pyrazol-3-yl) carboxylic acid fragments is described. The in vitro antibacterial activity of the new agents was evaluated against two fungal strains (Saccharomyces cerevisiae and Fusarium oxysporum f.sp albedinis) and against bacterial strains (Echerichia coli). A considerable activity was recorded with respect to the three studied micro-organisms. Structure activity relationship studies (SAR) reflect the effect of substituted pyrazolic fragment.

Keywords: Pyrazolic acids; Triphenyltin derivatives; Biological activities

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018007780867889

Publication date: 2007-07-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.