Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Ferreira, Leonardo G.
AU - Leitao, Andrei
AU - Montanari, Carlos A.
AU - Andricopulo, Adriano D.
TI - Hologram Quantitative Structure-Activity Relationships for a Class of Inhibitors of HIV-1 Protease
JO - Letters in Drug Design & Discovery
PY - 2007-07-01T00:00:00///
VL - 4
IS - 5
SP - 356
EP - 364
KW - HQSAR
KW - HIV
KW - AIDS
KW - Enzyme Inhibitors
KW - QSAR
N2 - HIV-specific protease inhibitors are fundamental antiviral drugs for people with HIV/AIDS. Hologram quantitative structure-activity relationships (HQSAR) were conducted on a class of 82 protease inhibitors. The final model obtained was used to predict the potency of 17 test set compounds. The predicted values were in good agreement with the experimental results.
UR - https://www.ingentaconnect.com/content/ben/lddd/2007/00000004/00000005/007aj
M3 - doi:10.2174/157018007780867825
UR - https://doi.org/10.2174/157018007780867825
ER -