Provider: Ingenta Connect Database: Ingenta Connect Content: application/x-research-info-systems TY - ABST AU - Ferreira, Leonardo G. AU - Leitao, Andrei AU - Montanari, Carlos A. AU - Andricopulo, Adriano D. TI - Hologram Quantitative Structure-Activity Relationships for a Class of Inhibitors of HIV-1 Protease JO - Letters in Drug Design & Discovery PY - 2007-07-01T00:00:00/// VL - 4 IS - 5 SP - 356 EP - 364 KW - HQSAR KW - HIV KW - AIDS KW - Enzyme Inhibitors KW - QSAR N2 - HIV-specific protease inhibitors are fundamental antiviral drugs for people with HIV/AIDS. Hologram quantitative structure-activity relationships (HQSAR) were conducted on a class of 82 protease inhibitors. The final model obtained was used to predict the potency of 17 test set compounds. The predicted values were in good agreement with the experimental results.





UR - https://www.ingentaconnect.com/content/ben/lddd/2007/00000004/00000005/007aj M3 - doi:10.2174/157018007780867825 UR - https://doi.org/10.2174/157018007780867825 ER -