Effect of Fluoxetine on Brain Oxidative Stress, Neuronal Damage and Behavioural Induced in the Olfactory Bulbectomy Model of Depression

Authors: Tunez, Isaac; Medina, Francisco J.; Jimena, Ignacio; Munoz, María del C.

Source: Letters in Drug Design & Discovery, Volume 4, Number 4, June 2007 , pp. 305-310(6)

Publisher: Bentham Science Publishers

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Abstract:

We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.

Keywords: Lipid Peroxidation; caspase-3; GSH-peroxidase; selective serotonin reuptake inhibitors; Open Field Test

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018007784620013

Publication date: 2007-06-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.