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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Publisher: Bentham Science Publishers

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Volume 4, Number 4, June 2007

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Articles

Inhibitory Effect of Acetogenins on Mammalian DNA Polymerase and Human Cancer Cell Growth
pp. 239-245(7)
Authors: Ishimaru, Chisato; Takeuchi, Toshifumi; Yonezawa, Yuko; Kuriyama, Isoko; Takemura, Msasaharu; Kato, Ikuo; Sugawara, Fumio; Yoshida, Hiromi; Mizushina, Yoshiyuki

Synthesis and Evaluation of 2'-Substituted Fendiline Analogues as Antileukemics
pp. 246-248(3)
Authors: Wilkinson, James A.; Rossington, Steven B.; Coe, Nicholas A.; Hirst, Nicholas; McGown, Alan T.; Leonard, John; Hussain, Nigel

Synthesis and Antitumor Properties of N1-(Hydroxymethyl Phenylmethyl) Pyrimidine Derivatives and their Intermediates
pp. 249-256(8)
Authors: Chen, Liying; Kode, Nageswara; Murthy, Devangachinta; Phadtare, Shashikant

Novel, Acidic CCR2 Receptor Antagonists: Lead Optimization
pp. 263-271(9)
Authors: Dasse, O. A.; Evans, J. L.; Zhai, H.-X.; Zou, D.; Kintigh, J. T.; Chan, F.; Hamilton, K.; Hill, E.; Eckman, J. B.; Higgins, P. J.; Volosov, A.; Collart, P.; Nicolas, J.-M.; Kondru, R.K.; Schwartz, C.E.

An Alternative Method for the Synthesis of Tetraketones and their Lipoxygenase Inhibiting and Antioxidant Properties
pp. 272-278(7)
Authors: Mohammed Khan, Khalid; Murtaza Maharvi, Ghulam; Ahmed Nawaz, Sarfraz; Perveen, Shahnaz; Iqbal Choudhary, Muhammad

Synthesis of 18F-labeled Neurotensin(8-13) via Copper-Mediated 1,3-Dipolar [3+2]Cycloaddition Reaction
pp. 279-285(7)
Authors: Ramenda, Theres; Bergmann, Ralf; Wuest, Frank

A Novel Descriptor Histogram Filtering Method for Database Mining and the Identification of Active Molecules
pp. 286-292(7)
Authors: Wang, Yuan; Godden, Jeffrey W.; Bajorath, Jurgen

Target-Oriented Synthesis of Antiparasitic 2-Hetaryl Substituted Quinolines Based on Imino Diels-Alder Reactions
pp. 293-296(4)
Authors: Kouznetsov, Vladimir V.; Vargas Mendez, Leonor Y.; Milena Leal, Sandra; Mora Cruz, Uriel; Andres Coronado, Carlos; Melendez Gomez, Carlos M.; Romero Bohorquez, Arnold R.; Escobar Rivero, Patricia

In vitro Antimicrobial Activity of Liposomes Containing Ciprofloxacin,Meropenem and Gentamicin Against Gram-Negative Clinical Bacterial Strains
pp. 297-304(8)
Authors: Gubernator, Jerzy; Drulis-Kawa, Zuzanna; Dorotkiewicz-Jach, Agata; Doroszkiewicz, Wlodzimierz; Kozubek, Arkadiusz

Effect of Fluoxetine on Brain Oxidative Stress, Neuronal Damage and Behavioural Induced in the Olfactory Bulbectomy Model of Depression
pp. 305-310(6)
Authors: Tunez, Isaac; Medina, Francisco J.; Jimena, Ignacio; Munoz, María del C.

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