Synthesis and Binding Properties of New Endothelin Receptor Ligands

Authors: Modica, Maria; Salerno, Loredana; Pittala, Valeria; Romeo, Giuseppe; Siracusa, Mariangela; Mereghetti, Ilario; Cagnotto, Alfredo; Mennini, Tiziana

Source: Letters in Drug Design & Discovery, Volume 4, Number 3, April 2007 , pp. 232-238(7)

Publisher: Bentham Science Publishers

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Abstract:

In this paper we report the synthesis of a new series of benzenesulfonamides and the evaluation of their binding properties on ETAh and ETBh receptor subtypes. Some new derivatives behave as selective ETAh receptor ligands and among them, 2-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-(2,4,6- trimethylphenyl)benzamide (23) was the most interesting.

Keywords: Hypertension; Endothelins; G protein-coupled receptors; ET receptors; Benzenesulfonamides; Binding properties

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018007780077426

Affiliations: 1: Dipartimento di Scienze Farmaceutiche, Università di Catania, Viale A. Doria 6, 95125 Catania,Italy.

Publication date: 2007-04-01

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