BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury

Authors: Asaf, Roy; Blum, Shany; Miller-Lotan, Rachel; Levy, Andrew P.

Source: Letters in Drug Design & Discovery, Volume 4, Number 2, March 2007 , pp. 160-162(3)

Publisher: Bentham Science Publishers

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Abstract:

Oxidative stress is responsible for myocardial injury occurring after ischemia and reperfusion (IR) and has been shown to be modulated by the Haptoglobin (Hp) genotype. In this manuscript we demonstrate that the antioxidant BXT -51072, a glutathione peroxidase synthetic mimic, provides protection against IR injury in a Hp genotype dependent fashion.

Keywords: Diabetes; Myocardial ischemia-reperfusion; Oxidative stress; BXT-51072

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018007779422479

Affiliations: 1: Technion Faculty of Medicine, Haifa, 31096, Israel.

Publication date: 2007-03-01

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