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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Publisher: Bentham Science Publishers

Volume 4, Number 2, March 2007
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Articles

Symmetrical Derivatives of C2-Substituted Pyrrolo[2,3-f]quinolines:Synthesis, Cytotoxicity and Drug Delivery Studies
pp. 87-91(5)
Authors: Tsotinis, Andrew; Vlachou, Marilena; Gerasimopoulou, Maria; Eikosipentaki, Aphrodite; Ioannidis, Constantine; Klouvidaki, Anna; Afroudakis, Pandelis A.; Moreau, Dimitri; Roussakis, Christos

Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells
pp. 92-98(7)
Authors: Chittimalla, Chandrashekhar; Dalkara, Deniz; Zuber, Guy

Fragment Based Approach for the Investigation of HIV-1 Integrase Inhibition
pp. 99-105(7)
Authors: Polanski, J.; Niedbala, H.; Musiol, R.; Podeszwa, B.; Tabak, D.; Palka, A.; Mencel, A.; Mouscadet, J.-F.; Le Bret, M.

Classical and Hologram QSAR Studies on a Series of Tacrine Derivatives as Butyrylcholinesterase Inhibitors
pp. 106-113(8)
Authors: Castilho, M. S.; C. Guido, R. V.; Andricopulo, A. D.

Synthesis and In Vitro Inhibitory Potential Towards Urease of 9-Anilinoacridines and Aciridinyl Hydrazides
pp. 114-121(8)
Authors: Mohammed Khan, Khalid; Akbar Rao, Nosheen; Arif Lodhi, M.; Perveen, Shahnaz; Iqbal Choudhary, M.; Voelter, Wolfgang

Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study
pp. 122-127(6)
Authors: Bacilieri, Magdalena; Kaseda, Chosei; Spalluto, Giampiero; Moro, Stefano

Non-Covalent Binding of Disodium Disuccinate Astaxanthin to the Catalytic Site of Phosphodiesterase 5A: A Molecular Modeling Study
pp. 128-136(9)
Authors: Hazai, Eszter; Bikadi, Zsolt; Zsila, Ferenc; Lockwood, Samuel F.

Design and In Vitro Evaluation of Five Inhibitors of Mycobacterium Tuberculosis
pp. 137-143(7)
Authors: Bartzatt, Ronald; G. Cirillo, Suat L.; Cirillo, Jeffrey D.

Design, Synthesis and Biological Testing of Cyclohexenone Derivatives of Combretastatin-A4
pp. 144-148(5)
Authors: Ruprich, Jennifer; Prout, Andrew; Dickson, John; Younglove, Brent; Nolan, Lawrence; Baxi, Khyati; LeBlanc, Regan; Forrest, Lori; Hills, Patrice; Holt Jr, Herman; Mackay, Hilary; Brown, Toni; Mooberry, Susan L.; Lee, Moses

Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions
pp. 149-153(5)
Authors: Vieira De Almeida, Mauro; Vinicius de Nora Souza, Marcus; Rezende Barbosa, Nadia; Pittella Silva, Frederico; Wilson Amarante, Giovanni; Helena Cardoso, Sílvia

Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines
pp. 154-159(6)
Authors: Everson da Silva, Luiz; Carlos Joussef, Antonio; Kramer Pacheco, Leticia; Bibas Legat Albino, Danielle; Mauricio Camilo Duarte, Anita; Steindel, Mario; Andrade Rebelo, Ricardo

BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury
pp. 160-162(3)
Authors: Asaf, Roy; Blum, Shany; Miller-Lotan, Rachel; Levy, Andrew P.

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