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Generation of a Droplet Inside a Microbubble with the Aid of an Ultrasound Contrast Agent: First Result

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New ultrasound contrast agents that incorporate a therapeutic compound have become of interest. Such an ultrasound contrast agent particle might act as the vehicle to carry a drug or gene load to a perfused region of interest. The load could be released with the assistance of ultrasound. Generally, an increase in shell thickness increases the acoustic amplitude needed to disrupt a bubble. High acoustic amplitudes, however, have been associated with unwanted effects on cells. It would be interesting to incorporate a droplet containing drugs or genes inside a microbubble carrier. A liquid core surrounded by a gas encapsulation has been referred to as antibubble. In this paper, the creation of an antibubble with the aid of ultrasound has been demonstrated with high-speed photography.

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Keywords: Antibubble; Drug delivery; High-speed photography; Ultrasound contrast agent

Document Type: Research Article

Affiliations: Institute for Medical Engineering, Ruhr-Universit├Ąt Bochum, Building IC, 6/144, D-44780 Bochum,Germany.

Publication date: 2007-01-01

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