Amphibian Secretions for Drug Discovery Studies: A Search for New Antiparasitic and Antifungal Compounds

Authors: Gustavo Tempone, Andre1; de Souza Carvalho Melhem, Marcia1; Oliveira Prado, Frederico1; Motoie, Gabriela1; Mitsuyoshi Hiramoto, Roberto1; Maria Antoniazzi, Marta1; Fernando Baptista Haddad, Celio1; Jared, Carlos1

Source: Letters in Drug Design & Discovery, Volume 4, Number 1, January 2007 , pp. 67-73(7)

Publisher: Bentham Science Publishers

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases.

Keywords: Peptides; Secretions; Amphibians; Leishmania; Trypanosoma; Antimicrobial

Document Type: Research article

DOI: 10.2174/157018007778992856

Affiliations: 1: Lab. Toxinologia Aplicada,Departamento de Parasitologia, Instituto Adolfo Lutz Av. Dr. Arnaldo 355,8° andar CEP 01246-000 Sao Paulo Brasil.

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A