Amphibian Secretions for Drug Discovery Studies: A Search for New Antiparasitic and Antifungal Compounds

Authors: Gustavo Tempone, Andre; de Souza Carvalho Melhem, Marcia; Oliveira Prado, Frederico; Motoie, Gabriela; Mitsuyoshi Hiramoto, Roberto; Maria Antoniazzi, Marta; Fernando Baptista Haddad, Celio; Jared, Carlos

Source: Letters in Drug Design & Discovery, Volume 4, Number 1, January 2007 , pp. 67-73(7)

Publisher: Bentham Science Publishers

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Abstract:

The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases.

Keywords: Peptides; Secretions; Amphibians; Leishmania; Trypanosoma; Antimicrobial

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018007778992856

Affiliations: 1: Lab. Toxinologia Aplicada,Departamento de Parasitologia, Instituto Adolfo Lutz Av. Dr. Arnaldo 355,8° andar CEP 01246-000 Sao Paulo Brasil.

Publication date: 2007-01-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.