Synthesis and Biochemical Evaluation of a Range of Non-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of the Enzyme Complex 17α -Hydroxylase/17,20-Lyase (P45017α)

Authors: Owen, Caroline P.; Patel, Chirag H.; Dhanani, Sachin; Ahmed, Sabbir

Source: Letters in Drug Design & Discovery, Volume 3, Number 10, December 2006 , pp. 761-765(5)

Publisher: Bentham Science Publishers

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Abstract:

We report the synthesis and evaluation of a range of triazole-based inhibitors of the two components of 17α-hydroxylase/17,20-lyase (P45017α). The results show that the compounds were poor inhibitors of 17α- OHase in comparison to lyase; they are therefore good lead compounds in the search for selective inhibitors of P45017α.

Keywords: 17α-Hydroxylase; 17; 20-Lyase; P45017α; Synthesis; Evaluation; Triazole

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018006778631857

Affiliations: 1: Department of Pharmacy,School of Pharmacy and Chemistry, Kingston University, Penrhyn Road,Kingston upon Thames, Surrey, KT1 2EE, UK.

Publication date: 2006-12-01

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