Eicosanoids as Therapeutic Targets in Asthma

Authors: Rastogi, P.; McHowat, J.

Source: Letters in Drug Design & Discovery, Volume 3, Number 9, November 2006 , pp. 668-674(7)

Publisher: Bentham Science Publishers

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Abstract:

Asthma is a chronic inflammatory disease of the airways associated with variable airflow obstruction and increased responsiveness to a variety of stimuli. Arachidonic acid metabolites play an important role in the pathophysiology of asthma and in this review we examine the major products of the lipoxygenase and cycloxygenase pathways, their effects on the airways and the current strategies used to target them.

Keywords: Arachidonic acid; Phospholipase A2; Lipoxygenase; Thromboxanes; Cycloxygenase

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018006778341165

Affiliations: 1: Department of Pathology,Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis,MO 63104, USA.

Publication date: 2006-11-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.