Utilizing IL-12, IL-15 and IL-7 as Mucosal Vaccine Adjuvants

Authors: Stevceva, Liljana; Moniuszko, Marcin; Grazia Ferrari, Maria

Source: Letters in Drug Design & Discovery, Volume 3, Number 8, October 2006 , pp. 586-592(7)

Publisher: Bentham Science Publishers

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Abstract:

In this paper we review and discuss three of the most exciting and promising cytokines for therapeutic intervention and immunomodulation of immune responses including those on mucosal surfaces. The main properties of IL-12, IL-15 and IL-7 are described and the studies utilizing these cytokines as immunomodulators and vaccine adjuvants discussed.

Keywords: IL-12; IL-15; IL-7; Mucosal; Vaccine

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018006778194655

Affiliations: 1: Partners AIDS Research Center, Department of Infectious Diseases, MGH, Harvard Medical School, CNY, Building 149, 13th street, Room 5423e, Charlestown, MA 02129, USA.

Publication date: 2006-10-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.