Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids

Authors: Moulisova, Vladimira; Sebestian, Jiri; Jedlickova, Olga; Jegorov, Alexandr; Sebestianova, Stepanka B.

Source: Letters in Drug Design & Discovery, Volume 3, Number 6, August 2006 , pp. 429-435(7)

Publisher: Bentham Science Publishers

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Abstract:

Interactions between cyclosporin A and three silymarin flavonoids (silybin, silydianin, and silychristin) were studied on the rat hepatocyte plasma membrane using the replacement of [3H]cyclosporin A by silymarin flavonoids. It was found that flavonoids significantly replaced CsA from its binding to the rat hepatocyte plasma membrane. It seems that these two types of compounds are competitors at the same binding site of the plasma membrane receptor.

Keywords: Cyclosporin A; silymarin flavonoids; hepatocytes; membrane transport

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018006777805567

Affiliations: 1: Department of Autotrophic Microorganisms, Institute of Microbiology ASCR, Opatovicky mlyn 379 81 Trebon, Czech Republic.

Publication date: 2006-08-01

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