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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Publisher: Bentham Science Publishers

Volume 3, Number 6, August 2006
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Articles

Targeting the Epidermal Growth Factor Receptor Family in Radionuclide Therapy of Tumors-Signal Transduction and DNA Repair
pp. 357-368(12)
Authors: Lennartsson, Johan; Carlsson, Jorgen; Stenerlow, Bo

MDR Reversal by Deprenylated Tetracyclic and Hexacyclic Analogues of N-Acetylardeemin: Confirmation of the Ardeemin Pharmacophore
pp. 369-377(9)
Authors: Avendano, Carmen; Caballero, Esmeralda; Mendez-Vidal, Cristina; de Quesada, Ana R.; Carlos Menendez, J.

Coenzyme Q10 and Neurological Diseases: An Update
pp. 378-382(5)
Authors: Mancuso, Michelangelo; Choub, Anna; Filosto, Massimiliano; Petrozzi, Lucia; Cafforio, Gianfranco; Siciliano, Gabriele; Murri, Luigi

Lead Optimisation: Improving the Affinity of the Antiretrovirals Nelfinavir and Amprenavir for HIV-1 Protease
pp. 383-389(7)
Authors: Fernandes, P. A.; Araujo, M.L. A.C.; Barbosa, A. J.M.; Alves, C. N.; Ferreira, Z. Q.; R.-N. Gonzalez, C.; C. Lima, C.F. R.A.; Loureiro, S. I.E.; Magalhaes, J. M.T.; Maia, F. C.; Moura, S. A.; Peredo, E.M. M.; Perez, M.A. S.; Rodrigues, T.A. Q.; Pessoa, A.M. Q.; da Silva, C.A. M.; da Silva, J.P. A.; Ramos, M. J.

Utilization of Ribozymes as Antiviral Agents
pp. 390-404(15)
Authors: Benitez-Hess, M. L.; Alvarez-Salas, L. M.

Non-Classical Drug Metabolism Enzymes: The Curious Case of Phenylalanine 4-Monooxygenase
pp. 405-412(8)
Authors: Steventon, G. B.; Mitchell, S. C.

High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis
pp. 413-418(6)
Authors: Azzolina, O.; Collina, S.; Rossi, D.; Carnevale Baraglia, A.; Alcaro, S.; Artese, A.

Antitubercular Properties of Substituted Hydroxycyclohexadienones
pp. 419-423(5)
Authors: Shah, Manish; Wells, Geoffrey; Bradshaw, Tracey D.; Laughton, Charles A.; Stevens, Malcolm F.G.; Westwell, Andrew D.

Synthesis and In Vitro Anti-Tubercular Activity of a Series of N'- (Disubstitutedbenzoyl)Isoniazid Derivatives
pp. 424-428(5)
Authors: Neves Junior, Ivan; Lourenco, Maria C.S.; de Miranda, Guilherme d.e.B.P.; Vasconcelos, Thatyana R.A.; Pais, Karla C.; dos P. de A. Junior, Jose; Wardell, M. S.V.; Wardell, James L.; de Souza, V. N.

Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids
pp. 429-435(7)
Authors: Moulisova, Vladimira; Sebestian, Jiri; Jedlickova, Olga; Jegorov, Alexandr; Sebestianova, Stepanka B.

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