Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin

Authors: Kamal, Ahmed; Kumar, B. A.; Arifuddin, M.; Dastidar, Sunanda G.

Source: Letters in Drug Design & Discovery, Volume 3, Number 3, April 2006 , pp. 205-209(5)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $63.10 plus tax (Refund Policy)

Abstract:

Some new 4β-N-heteroaryl analogues of podophyllotoxin have been prepared by employing Red Phosphorous/I2 reagent system. These 4β-N-heteroaryl analogues have been evaluated for their cytotoxicity against six human cancer cell lines and some representative ones have shown promising anticancer activity.

Keywords: Epipodophyllotoxin; benzothiazoles; pyrimidines; anticancer activity

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157018006776286907

Affiliations: 1: Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad - 500007, India.

Publication date: 2006-04-01

More about this publication?

Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.