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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Publisher: Bentham Science Publishers

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Volume 3, Number 3, April 2006

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Articles

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Evaluation of the Effects of a New Drug on Brain Leukocyte Infiltration in an Experimental Model of Autoimmune Encephalomyelitis
pp. 138-148(11)
Authors: Mangas, A.; Covenas, R.; Bodet, D.; Dabadie, M. P.; Glaize, G.; Geffard, M.

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Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study
pp. 149-151(3)
Authors: Fiuza, S. M.; Amado, A. M.; Oliveira, Paulo J.; Sardao, Vilma A.; de Carvalho, L. A.E.B.; Marques, M. P.M.

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Synthesis and Evaluation of Calpain Inhibitors Carrying Muscle Cell Targeting Groups
pp. 152-158(7)
Authors: Weyermann, P.; Herzner, H.; Lescop, C.; Siendt, H.; Bolliger, R.; Hennebohle, M.; Rummey, C.; Briguet, A.; Courdier-Fruh, I.; Erb, M.; Foster, M.; J.P. Magyar; A. von Sprecher; T. Meier

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Regulation of MMP/TIMP Balance as Therapeutic Target in Pulmonary Diseases
pp. 159-171(13)
Authors: Martin-Chouly, Corinne A.E.; Guillot, Stephanie; Jouneau, Stephane; Caulet-Maugendre, Sylvie; Vernhet, Laurent; Lagente, Vincent; Delaval, Philippe

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HIF-1α as a Target for Drug Design in Ischemic Injury: Effect of Cobalt Treatment on Mitochondrial DNA Damage in Cells Exposed to H2O2
pp. 172-174(3)
Authors: Nomura, Yasutomo; Fujiwara, Hiroyuki; Ito, Kohei; Fuchigami, Hirobumi; Sato, Michihiko; Takahashi, Eiji; Hozumi, Yasukazu; Goto, Kaoru; Feng, Zhonggang; Nakamura, Takao

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5-Hydroxy-6-Quinaldic Acid as a Novel Molecular Scaffold for HIV-1 Integrase Inhibitors
pp. 175-178(4)
Authors: Polanski, J.; Niedbala, H.; Musiol, R.; Podeszwa, B.; Tabak, D.; Palka, A.; Mencel, A.; Finster, J.; Mouscadet, J.- F.; Bret, M. L.

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Synthesis and Evaluation of Hypolipidemic Properties of some Novel Derivatives of Thieno Oxazine and 5-Hydroxyindole-2-Carboxylic Acid
pp. 179-182(4)
Authors: Mohan, Sankar; Reddy, K. A.; Iqbal, Javed; Bhuniya, Debnath; Das, Saibal K.

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Preparation of a Cyclodextrin Conjugated With Two Arbutin Moieties as a Drug-Carrier Model, and its High Ability for the Inclusion of Doxorubicin
pp. 188-191(4)
Authors: Yamanoi, Takashi; Kobayashi, Natsumi; Takahashi, Keiko; Hattori, Kenjiro

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Synthesis and Biological Activity of 4-Amino-1-Methyl-5-Imidazolecarboxylic Acid Derivatives
pp. 192-199(8)
Authors: Regiec, A.; Mastalarz, H.; Miedzybrodzki, R.; Smietanska, K.; Jasztold-Howorko, R.

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Increasing the Odds of Drug Hit Identification by Screening Against Receptor Homologs?
pp. 200-204(5)
Authors: Ji, Z. L.; Li, Z. R.; Wang, J. F.; Cai, C. Z.; Han, L. Y.; Zheng, C. J.; Chen, Y. Z.

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Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin
pp. 205-209(5)
Authors: Kamal, Ahmed; Kumar, B. A.; Arifuddin, M.; Dastidar, Sunanda G.

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