Synthesis and Cyclooxygenase-2 (COX-2) Inhibiting Properties of 1,5- Diarylpyrazoles Possessing N-Substitution on the Sulfonamide (-SO2NH2) Moiety†

Authors: Pal, Manojit; Veeramaneni, Venugopal R.; Kumar, Sanjeev; Vangoori, Akhila; Mullangi, Ramesh; Misra, Parimal; Rajjak, Shaikh A.b.d.u.l.; Lohray, Vidya B.; Casturi, Seshagiri R.a.o.; Yeleswarapu, Koteswar R.a.o.

Source: Letters in Drug Design & Discovery, Volume 2, Number 4, June 2005 , pp. 329-340(12)

Publisher: Bentham Science Publishers

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Abstract:

A number of novel 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (-SO2NH2) moiety were synthesized and tested for COX-1/COX-2 inhibition in vitro. Many of these 1,1-dioxo-2,3- dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles, where the SO2NH2 group was a part of the fused ring, showed COX inhibitory activity. Few of them were identified as selective COX-2 inhibitors. Structure Activity Relationship study within the series are discussed.

Keywords: diarylpyrazoles; cox & cox inhibition; structure activity relationship (sar) study

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570180054038459

Affiliations: 1: Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500049, India.

Publication date: 2005-06-01

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