Synthesis of Azetidin-2-One Derivatives as Inhibitor of Secretory Phospholipase A2 with Anti-Inflammatory Activity

Authors: Yerigeri, Mayur C.¹; Murari, Satish K.¹; Mohammed, Salahuddin¹; Math, Shanta K.S.¹; Thimmaiah, Kuntebommanahalli N.¹; Vishwanath, Bannikuppe S.a.n.n.a.n.a.i.k.¹

Source: Letters in Drug Design & Discovery, Volume 2, Number 4, June 2005 , pp. 307-310(4)

Publisher: Bentham Science Publishers

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Abstract:

The title compounds have been synthesized and tested for structure activity relationship for Phospholipase A2 (PLA2) [E.C. 3.1.1.4] enzyme inhibition. The in vitro PLA2 enzyme inhibitory activity of azetidin-2-one derivatives and in vivo anti-inflammatory activity studies using mice are highlighted. The results show that some azetidin-2-one derivatives are very good PLA2 inhibitors and can also be used as antiinflammatory drugs.

Keywords: phospholipase; anti-inflammatory; azetidin-one derivatives

Document Type: Review article

DOI: 10.2174/1570180054038404

Affiliations: 1: Department of Medicinal Chemistry, V.L. College of Pharmacy, Raichur 584103, India.

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