Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies

Authors: Olea-Azar, Claudio1; Rigol, Carolina1; Mendizabal, Fernando1; Cerecetto, Hugo1; Maio, Rossanna D.1; Gonzalez, Mercedes1; Porcal, Williams1; Morello, Antonio1; Repetto, Yolanda1; Maya, Juan D.i.e.g.o.1

Source: Letters in Drug Design & Discovery, Volume 2, Number 4, June 2005 , pp. 294-301(8)

Publisher: Bentham Science Publishers

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Abstract:

In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic voltammetry and electron spin resonance spectroscopy were used to predict the bio-reduction processes. Effects on the parasitic respiration were studied.

Keywords: oxadiazole n-oxide; trypanosoma cruzi; cyclic voltammetry; esr spectroscopy; cellular respiration

Document Type: Review article

DOI: 10.2174/1570180054038341

Affiliations: 1: Departamento de Quimica Inorganica y Analítica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Casilla 233, Santiago 1, Chile.

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