Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies

Authors: Olea-Azar, Claudio; Rigol, Carolina; Mendizabal, Fernando; Cerecetto, Hugo; Maio, Rossanna D.; Gonzalez, Mercedes; Porcal, Williams; Morello, Antonio; Repetto, Yolanda; Maya, Juan D.i.e.g.o.

Source: Letters in Drug Design & Discovery, Volume 2, Number 4, June 2005 , pp. 294-301(8)

Publisher: Bentham Science Publishers

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Abstract:

In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic voltammetry and electron spin resonance spectroscopy were used to predict the bio-reduction processes. Effects on the parasitic respiration were studied.

Keywords: oxadiazole n-oxide; trypanosoma cruzi; cyclic voltammetry; esr spectroscopy; cellular respiration

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570180054038341

Affiliations: 1: Departamento de Quimica Inorganica y Analítica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Casilla 233, Santiago 1, Chile.

Publication date: 2005-06-01

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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.