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Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Publisher: Bentham Science Publishers

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Volume 2, Number 1, February 2005

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Book review

Graphical Abstracts
pp. i-v(5)

Review article

RNA Silencing Technologies in Drug Discovery and Target Validation
pp. 1-18(18)
Authors: Elizabeth Rayburn; Hui Wang; Jie He; Ruiwen Zhang

Farnesyltransferase Inhibitors: Overview of their Action and Role in Solid Malignancy Therapy
pp. 26-35(10)
Authors: Stefano Margaritora; Alfredo Cesario; Venanzio Porziella; Pierluigi Granone; Alessia Catassi; Patrizia Russo

2,3,4,5- Tetrahydro- 1-Benzoxepines a Novel Class of Anti-Implantation Agents
pp. 36-39(4)
Authors: Vishnu K. Tandon; Sanjay Rai

Design of a Heteroaryl Modified, 1,5-Disubstituted Pyrazole Cyclooxygenase-2 (COX-2) Selective Inhibitor
pp. 40-43(4)
Authors: M. Ezawa; D. S. Garvey; D. R. Janero; S. P. Khanapure; L. G. Letts; A. Martino; R. R. Ranatunge; D. J. Schwalb; D. V. Young

L-Carnitine Effect upon Iron Growth Inhibition on Saccharomyces cerevisiae
pp. 44-47(4)
Authors: C. A. Stella; H. I. Burgos; M. Salellas; M. L. Cristaldo; E. H. Ramos; N. Kriguer

Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs
pp. 51-54(4)
Authors: M. S. Levi; M. O.F. Khan; R. F. Borne

Synthesis and Biological Activity of C-8 Fluoroaryl Substituted Pyrimidine Linked-Pyrrolobenzodiazepine Conjugates
pp. 55-61(7)
Authors: Ahmed Kamal; K. L. Reddy; V. Devaiah; N. Shankaraiah; M. S.h.i.v.a. Kumar; G. S.K. Reddy

Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Antiinflammatory 1,3,4-Thiadiazole Derivatives
pp. 62-67(6)
Authors: L. S. Varandas; C. A.M. Fraga; A. L.P. Miranda; E. J. Barreiro

Pharmacological Profile of New Deamino Analogues of Sabarubicin (MEN 10755)
pp. 68-73(6)
Authors: M. Bigioni; C. Salvatore; A. Cipollone; M. Berettoni; C. A. Maggi; M. Binaschi

Addendum

Author Index to Volume 1
pp. 82-85(4)
Author: Bentham Science Publishers

Subject Index to Volume 1
pp. 86-91(6)
Author: Bentham Science Publishers

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