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Combination Therapy of Statins with Ezetimibe

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Abstract:

Ezetimibe is a cholesterol absorption inhibitors that blocks the intestinal absorption of cholesterol and biliary cholesterol without affecting the uptake of triglyceride or fat-soluble vitamins. The co-administration of ezetimibe with statin has been shown to produce significant incremental reduction in LDL-C beyond that achieved with statin therapy alone. The efficacy and safety of this strategy has been studied in a several trials in a great number of patients. The mean difference between treatments significantly favoured the ezetimibe/statin combination over placebo/statin for total cholesterol (p < 0.0001), LDL-C (p < 0.0001) and HDL-C (p < 0.0001). The probability of reaching the LDL-C treatment goal was significantly higher for patients on ezetimibe/statin relative to those on placebo/ statin (p < 0.0001). Elevations in creatine kinase, alanine aminotransferase or aspartate aminotransferase that were considered as an adverse effect did not differ significantly between treatments. Ezetimibe co-administered with ongoing statin therapy provides significant additional lipid-lowering in patients not at LDL-C goal on statin therapy alone, allowing more patients to reach their LDL-C goal with no increment in the side-effects.





Keywords: Ezetimibe; HDL; LDL; cholesterol; meta-analysis; safety; statins

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/187152208784587953

Publication date: June 1, 2008

More about this publication?
  • Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in the medicinal chemistry and rational drug design for the discovery of new Immunology, Endocrine & Metabolic Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Immunology, Endocrine & Metabolic medicinal chemistry.

    Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Immunology, Endocrine & Metabolic drug discovery.
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