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Demonstration of the Efficacy of Statins in Resolution of Plaque Inflammation by Serial FDG Imaging

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Statins contribute to stabilization of atherosclerotic plaques not only by reduction in circulating levels of atherogenic lipoproteins, but also by pleiotropic effects such as resolution of plaque inflammation. 18F-fluorodeoxyglucose (FDG) imaging, which is commonly employed for the detection of malignant tumors, has been recently shown to identify inflamed atherosclerotic lesions, and prospective studies have demonstrated close relationship between FDG uptake and the extent of vascular inflammation. The FDG uptake is highly reproducible. Use of statins abrogates FDG uptake, suggesting favorable effect on plaque inflammation. Recent demonstration of FDG uptake in coronary vessels suggests that detection of vulnerable plaques may become a possibility.

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Keywords: Atherosclerosis; HMG-CoA reductase inhibitor; molecular imaging; positron emission tomography

Document Type: Research Article

Publication date: 2008-06-01

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  • Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in the medicinal chemistry and rational drug design for the discovery of new Immunology, Endocrine & Metabolic Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Immunology, Endocrine & Metabolic medicinal chemistry.

    Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Immunology, Endocrine & Metabolic drug discovery.
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