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Safety Aspects of Statins: Which Factors Create the Adverse Effects of Statins

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Statins have been shown to have beneficial effects on myocardial infarction, revascularization, stroke, and cardiovascular mortality in numerous clinical trials. Seven kinds of statins are available today and have different characteristics in their efficacy of LDLlowering, their metabolism and their adverse effects including hepatic injury, muscle disease, renal injury and neurologic injury. Muscle disease is the most discussed adverse effect with the use of statins including rhabdomyolysis, the most serious one. Hepatic injury with high dose statin use should be mentioned, although the incidence is low. Statins are well-tolerated and have been extremely well studied all over the world. As the contribution of statins in preventing cardiovascular events has already been proven, physicians should not hesitate to prescribe statins to patients not only with hypercholesterolemia, but also to those with high risks.

Keywords: Statin; cytochrome P-450 system; drug interaction; myopathy; rhabdomyolysis

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/187152208784587962

Publication date: June 1, 2008

More about this publication?
  • Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in the medicinal chemistry and rational drug design for the discovery of new Immunology, Endocrine & Metabolic Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Immunology, Endocrine & Metabolic medicinal chemistry.

    Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Immunology, Endocrine & Metabolic drug discovery.
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